Targeting a

Fuller Life

Rain Oncology develops innovative, targeted therapies to help patients with cancer get their life back.

We focus on cancers where we can genetically identify patients most likely to benefit from treatment.

milademetan clinical program

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Milademetan is an oral agent that targets the MDM2*-p53 interaction, a key mediator of many malignancies. Milademetan is currently in clinical development for patients with MDM2-dependent, TP53 wildtype cancers.

Resources & Publications

Rain in the News

Rain Oncology Provides Company Update and Outlines Strategic Priorities of Milademetan Clinical Programs
May 30, 2023 8:30 AM
NEWARK, Calif., May 30, 2023 – Rain Oncology Inc. (NasdaqGS: RAIN), (Rain), a clinical stage company developing precision oncology therapeutics today announced an update to its clinical strategy for milademetan, its small molecule inhibitor of the MDM2-p53 complex, to optimize Company resources. The Company is focused on reducing its cash burn with the expectation to extend cash runway to year-end 2026.
Rain Oncology Announces Topline Results from Phase 3 MANTRA Trial of Milademetan for the Treatment of Dedifferentiated Liposarcoma
May 22, 2023 8:00 AM
NEWARK, Calif., May 22, 2023 – Rain Oncology Inc. (NasdaqGS: RAIN), (Rain), a late-stage company developing precision oncology therapeutics with its lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53, today announced its topline pivotal Phase 3 MANTRA data. The trial, evaluating the efficacy, safety, and tolerability of milademetan in patients with dedifferentiated (DD) liposarcoma (LPS), did not meet its primary endpoint of progression free survival (PFS) by blinded independent central review compared to the standard of care, trabectedin.
Rain Oncology Reports First Quarter 2023 Financial Results and Highlights Recent Progress
May 11, 2023 4:05 PM
NEWARK, Calif., May 11, 2023 (GLOBE NEWSWIRE) -- Rain Oncology Inc. (NasdaqGS: RAIN), (Rain), a late-stage biotechnology company developing precision oncology therapeutics with a lead candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53, today reports financial results for the first quarter ended March 31, 2023, along with an update on the Company's key corporate highlights and upcoming milestones.