Targeting a

Fuller Life

Rain Oncology researches, develops and translates innovative targeted cancer therapies for patients

Rain oncology is focused on patients struggling with difficult cancers, and we help provide them hope to get their lives back.

Scientific programs

Rain’s programs  target oncogenic drivers for which it is able to genetically select patients it believes will most likely benefit.

MilademetaN

Rain’s lead drug candidate, milademetan, is an oral small molecule, inhibitor of mouse double minute 2 (MDM2). It is in clinical development  in patients with liposarcoma and other MDM2 - dependent cancers.

Rad52 Research program

Rain’s RAD52 research program is currently in preclinical development. RAD52 plays a central role in the DNA Damage Response (DDR) pathway.

Resources & Publications

Rain in the News

Rain Oncology to Participate in the 2023 Guggenheim Healthcare Talks Oncology Day Conference
January 31, 2023 8:00 AM
NEWARK, Calif., January 31, 2022 (GLOBE NEWSWIRE) -- Rain Oncology Inc. (NasdaqGS: RAIN), (“Rain”), a late-stage company developing precision oncology therapeutics with its lead product candidate, milademetan, an oral, small molecule inhibitor of the p53-MDM2 complex that reactivates p53, today announced that Avanish Vellanki, Chief Executive Officer of Rain, will be participating in a fireside chat at the Guggenheim Healthcare Talks Oncology Day Conference on Wednesday, February 8, 2023, at 9:35 a.m. ET, being held in New York, NY.
Phase 1 Clinical Data of Milademetan Published in Journal of Clinical Oncology
January 23, 2023 8:00 AM
NEWARK, Calif., January 23, 2023 (GLOBE NEWSWIRE) -- Rain Oncology Inc. (NasdaqGS: RAIN), (“Rain”), a late-stage company developing precision oncology therapeutics with its lead product candidate, milademetan, an oral, small molecule inhibitor of the p53-MDM2 complex that reactivates p53, today announced the publication of a peer-reviewed article titled, “A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients with Advanced Liposarcoma, Solid Tumors or Lymphomas” in the Journal of Clinical Oncology. Phase 1 clinical data in the paper highlight the activity and tolerability using intermittent dosing of milademetan across a range of tumor types including dedifferentiated liposarcoma (DD LPS), which represented the largest proportion of patients enrolled in the study (n=53).
Rain Therapeutics Inc. Announces Name Change to Rain Oncology Inc.
December 29, 2022 8:00 AM
NEWARK, Calif., December 29, 2022 (GLOBE NEWSWIRE) -- Rain Therapeutics Inc. (“Rain”) (NasdaqGS: RAIN), (Rain), a late-stage biotechnology company developing precision oncology therapeutics with a lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53, today announced that it will change its name to Rain Oncology Inc. effective tomorrow, December 30, 2022, to better reflect the company's focus on addressing unmet needs for cancer patients through precision oncology.